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2019 November 23, Michael J. Sofia, HCV: The Journey from Discovery to a Cure: Volume I, volume 31, Springer Nature, →ISBN, page 281:It was unclear why about a third of patients developed some degree of anorectal symptoms, but in clinical trials, fewer than 1% discontinued treatment because of these symptoms. We suspected that excipients or metabolites of telaprevir may be involved, and certain investigators performed endoscopy to look for inflammation or other lesions; none were found. This syndrome became known outside Vertex as “fire-arrhea” and could have led to a commercial disaster. Medical affairs did not have any specific interventions that were included in the clinical trials to draw upon.
2022 May 22, Matt Lawton, “Papa Don't Fiend Adventure” (9:06 from the start), in The Great North, season 2, episode 22, spoken by Judy Tobin (Jenny Slate):“I told you kids there was a looming forest fire and we had to go, but there was no forest fire. Just a log fire. Logs of human excrement.” “Hmm. A fire-arrhea.” “Indeed.”