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Two means of accounting for the appearance of Latin modus in the second declension exist.
The e-grade s-stem noun may have coexisted with an o-grade *-os noun *modos. In Latin, the o-grade noun borne out by modus ousted the s-stem noun, and the vocalism of all surviving derivatives of the s-stem noun was adjusted to match that of modus.
Schrijver alternatively posits that *medos, an original s-stem would simply turn to *modos via a sound law on the way to Latin, and the second declension would have been acquired secondarily.
^ De Vaan, Michiel (2008) “modus”, in Etymological Dictionary of Latin and the other Italic Languages (Leiden Indo-European Etymological Dictionary Series; 7), Leiden, Boston: Brill, →ISBN, pages 384-5
^ Schrijver, Peter C. H. (1991) The reflexes of the Proto-Indo-European laryngeals in Latin (Leiden studies in Indo-European; 2), Amsterdam, Atlanta: Rodopi, →ISBN, page 470