Here are some weird English words from the official Scrabble word list (which is based on the Collins Dictionary) — weirdness here being measured in unique n-graphs (sequences of n consecutive letters).
I hope to write original definitions for some red links and remove blue ones that have English definitions. Feel free to help.
accoyld agryzing alloiostrophos amarna anadyomene antwackie apgar ashraf atoks attaskt avyzing awato aygre bajris batteilant bembixes benjes bethesdas beuncled billyohs blaize bockedy bohs bowrs boygs brachyaxes breiing broadbrush byding byking bylive byrlakin byrled byrls caaed caaing chiao chynd clodly coomceiled cuifs curny daeing dasypaedal daubry dawbry deasiuls deaws deawy deckoing deely dekeing dekkoed desoeuvre dicycly dowlney dropfly embayld emmys endodyne ennuyee ewftes ewked ewking ewks faaing fegs fehs feying fiky flamms flirs floatcut fodgel fohs foolbegged forfeuchen forfochen forhooieing forswonck fouer galyacs gawsy gedeckts geyan gjus glaceed glaceing gongyos gonyses goujeers goxes grannieing griesy grimlooked grufted gryesy guvs gynnies gynny haafs halfseriously havdolohs heryed hewgh highblooded hoaed hoaing hohed homologumena hupiro hwyls hyperlydian hypoaeolian indolebutyric introfying isoetes jagaed jokol jowed jowing judy kaeing kaes kaies kantikoyed kantikoying kelyphitic kenafs kernmantel kirby kletterschuhe kokiri kumbaloi lehrjahre lewdsbies lewdsby lezes lifull looves loslyfs loued lowsit luzzes lyms mahewus makutuing malwas mashgihim matlos mawbound mawger mawing metavanadic meuniere mihied mihiing mips mixobarbaric moryah mouvemente mudejares mycs myxos nanua naythles noahs nowty nuraghic nyed ockodols ogmic omovs opgefok orestunck orihou orthotungstic orthovanadic oughlying overscutched palaeethnology papauma paysd peeoys pemphixes perfay perissosyllabic perjinkity pilniewinks pinnoed pioted pioys plouky pneumodynamics pompeying poogyes prajnas proyns purpy pyeing quyting rabbitohs ramgunshoch reaedifyed reaedifyes rectirostral rhies rightos roarming rowmes rozeting rubbidy ryfe ryking rymming sadzas saltoed sanghs sayne scapigerous sceptry schappeing schmalzes scryde sculduddries sculduddry seewing shantihs siamezing simioid sirihs skivy skyfed skyfing slairgs sleepry slubbs soojeys souct soyuzes spags spayds speugs spifs spoylefull sris steepeup stolenwise styting sweyed sweying syed syeing tadvance talcked tanhs tecs tikiing toazing toytown transfard trioxoboric troely trueman tuktus tuptowing typps unbeen unhouzzled unnaneld unpinkt upgone uphudden upryst vawntie vawtes vehmique verdelhos veronique villagioes viold visieing vizying waacs wadts webfed weyard whaizling wheezling whenuas williams withhault wofs wormflies wormfly wuds wuses yeving yitten yuky