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English
Etymology
Coined by Thea D. Tlsty et al. in a 2001 paper. Explained as Latin agōn (“contest”) + -escence.[1]
Noun
agonescence (uncountable)
- (biology) A halting of the growth of a colony of cells.
References
- ^ Thea D. Tlsty et al. (2001) “Loss of Chromosomal Integrity in Human Mammary Epithelial Cells Subsequent to Escape from Senescence”, in Journal of Mammary Gland Biology and Neoplasia, volume 6, number 2:
[page 237] After a second period of exponential growth, these epithelial cells enter a second growth plateau, P2 […] that we have termed agonescence.
[page 241] It seems logical that the first plateau be called by its original descriptive name, selection. However, it would be useful to suggest a new name for P2 since it is neither senescence nor viral oncoprotein-induced crisis. The most prominent attributes of the mammary epithelial cells at P2 are their dramatic accumulation of chromosomal rearrangements and the dynamic state of proliferation
and death. The Latin root “agon” is defined as a violent struggle that precedes death or a strong sudden display. An agonescent cell would be one that is engaged in the violent struggle that precedes death.