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2007 March 20, Lawrence K. Altman, “Rise of a Deadly TB Reveals a Global System in Crisis”, in New York Times:
XDR-TB is defined as tuberculosis that is resistant to the two most important antituberculosis drugs (isoniazid and rifampin), along with […] a member of the fluoroquinolone class and at least one of three others (capreomycin, kanamycin and amikacin).