Hello, you have come here looking for the meaning of the word binimetinib. In DICTIOUS you will not only get to know all the dictionary meanings for the word binimetinib, but we will also tell you about its etymology, its characteristics and you will know how to say binimetinib in singular and plural. Everything you need to know about the word binimetinib you have here. The definition of the word binimetinib will help you to be more precise and correct when speaking or writing your texts. Knowing the definition ofbinimetinib, as well as those of other words, enriches your vocabulary and provides you with more and better linguistic resources.
2017 February 28, Johanna C. Bendell et al., “A Phase 1 Dose-escalation and Expansion Study of Binimetinib (MEK162), a Potent and Selective Oral MEK1/2 Inhibitor”, in British Journal of Cancer, volume 116, Edinburgh: Nature Research, →DOI, →ISSN, →OCLC, page 576, column 1:
Binimetinib (MEK162; ARRY-438162) is a potent, adenosine triphosphate-uncompetitive, highly selective allosteric inhibitor of MEK1/2 with demonstrated on-target activity in vitro and in vivo, including models of cancer [...] In vivo, binimetinib displays broad anti-tumour activity in xenograft models derived from melanoma, colorectal cancer, non-small cell lung cancer (NSCLC), fibrosarcoma, cholangiocarcinoma, and pancreatic cancer. These non-clinical data support the use of binimetinib in a wide variety of tumour types, with a priority in tumours with aberrantly activated MAPK pathway signalling.
2017 April 1, Reinhard Dummer et al., “Binimetinib versus Dacarbazine in Patients with Advanced NRAS-mutant Melanoma (NEMO): A Multicentre, Open-label, Randomised, Phase 3 Trial”, in David Collingridge, editor, The Lancet Oncology, volume 18, number 4, London: Lancet Publishing Group, →DOI, →ISSN, →OCLC, pages 435–445:
Binimetinib improved progression-free survival compared with dacarbazine and was tolerable. Binimetinib might represent a new treatment option for patients with NRAS-mutant melanoma after failure of immunotherapy.
2018, Laurence Brunton, Bjorn Knollman, Randa Hilal-Dandan, Goodman and Gilman’s The Pharmacological Basis of Therapeutics, 13th edition, New York, N.Y.: McGraw Hill Professional, →ISBN, page 1212:
Under development are binimetinib, a MEK inhibitor being studied in patients with NRAS-mutant melanoma, and encorafinib, a BRAF inhibitor being used in combination with binimetinib for patients with BRAF-mutant melanoma.
2018, Shane Y. Morita et al., Textbook of General Surgical Oncology, New York, N.Y.: McGraw Hill Professional, →ISBN, page 187:
The initial report of the phase I/II combination trial of encorafenib and binimetinib reported on 9 BRAF inhibitor naive and 14 BRAF inhibitor pretreated patients with metastatic BRAF mutant melanoma across a range of doses.
2019 July 20, Heidi Finnes, “Binimetinib (Mektovi®)”, in Oncology Times: The Newspaper for Specialists in Cancer, volume 41, number 14, Philadelphia, Pa.: Lippincott Williams & Wilkins, →DOI, →ISSN, →OCLC, page 8:
Binimetinib is an oral reversible inhibitor of mitogen-activated extracellular signal-regulated kinase (MEK) 1/2. [...] Binimetinib inhibits MEK 1/2 downstream from BRAF and halts cancer cell signaling and survival. [...] Binimetinib is approved in combination with encorafenib, a BRAF inhibitor, for the treatment of unresectable or metastatic melanoma with a BRAF V600E/K mutation, as detected by an FDA-approved test.
Special Considerations [...] 7. Monitor patients for an increased risk of new primary cancers, both cutaneous and non-cutaneous, while on therapy and for up to 6 months following the last dose of binimetinib. [...] 10. Baseline and periodic CPK levels while on therapy, as rhabdomyolysis has been observed with binimetinib therapy.
2020, Gail M. Wilkes, Margaret Barton-Burke, “Molecular Targeted Therapy”, in Oncology Nursing Drug Handbook 2020–2021, Burlington, Mass.: Jones & Bartlett Learning, →ISBN, →ISSN, page 548:
Binimetinib is given in combination with encorafenib as each drug targets a different kinase in the RAS/RAF/MEK/ERK pathway to stop malignant cell proliferation and to tell the cells to die (undergo apoptosis). [...] Terminal half-life of binimetinib is 3.5 hours. [...] No clinically significant changes in binimetinib exposure were seen in patients with severe renal impairment.
Translations
drug that inhibits mitogen-activated protein kinase kinase
binimetinib on Wikipedia.Wikipedia 