calcilytic
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English
Noun
calcilytic (plural calcilytics)
- Any antagonist of a calcium-sensing receptor; especially such a drug used for the treatment of osteoporosis
- 2015 September 17, “Inhibition of Excessive Cell Proliferation by Calcilytics in Idiopathic Pulmonary Arterial Hypertension”, in PLOS ONE, :
- Treatment with NPS2143, an antagonist of CaSR or calcilytic, clearly suppressed the cell proliferation in a concentration-dependent manner (IC 50 = 2.64 μM) in IPAH-PASMCs, but not in normal and CTEPH PASMCs. Another calcilytic, Calhex 231, which is structurally unrelated to NPS2143, also concentration-dependently inhibited the excessive proliferation of IPAH-PASMCs (IC 50 = 1.89 μM).