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Borrowed from Latincancer(“crab”), a calque of Ancient Greekκαρκίνος(karkínos, “crab; ulcer; cancer”) (possibly cognate), applied to cancerous tumors because the enlarged veins resembled the legs of a crab. Doublet of canker and chancre.
2006, Edwin Black, chapter 1, in Internal Combustion:
If successful, Edison and Ford—in 1914—would move society away from the[…]hazards of gasoline cars: air and water pollution, noise and noxiousness, constant coughing and the undeniable rise in cancers caused by smoke exhaust particulates.
Risk is everywhere. From tabloid headlines insisting that coffee causes cancer (yesterday, of course, it cured it) to stern government warnings about alcohol and driving, the world is teeming with goblins. For each one there is a frighteningly precise measurement of just how likely it is to jump from the shadows and get you.
Cancers are common diseases; in the aggregate, they are among the leading causes of death nationally and worldwide, and their incidence is increasing as the population ages.
1991, Charlie Peacock (lyrics and music), “In the Light”:
The disease of the self runs through my blood; It's a cancer fatal to my soul.
1999, Bruce Clifford Ross-Larson, Effective Writing, page 134:
Sierra Leone's post-dictator problems are almost absurd in their breadth. It once exported rice; now it can't feed itself. The life span of the average citizen is 39, the shortest in Africa. Unemployment stands at 87 percent and tuberculosis is spreading out of control. Corruption, brazen and ubiquitous, is a cancer on the economy.
In classical Latin, usually declined as a masculine second-declension noun with the stem cancro-.
Third-declension forms built on a stem cancer- also existed, but were much less frequent. Attested forms include:
genitive singular canceris (Lucretius, De Rerum Natura 5.617)
accusative plural cancerēs (Cato the Elder, De Agri Cultura 157.3.4)
The grammarians Charisius and Priscian describe a use as a neuter noun, with Priscian specifying that this applies when the word is used for the illness; the neuter occurs sporadically in later Christian authors.[1]
^ Jerry Russell Craddock, "The Romance descendants of Latin cancer and vespa" in Romance Philology, Vol. 60 (2006), Homage Issue: Special Combined issue of Romance Philology In Celebration of the 60th Anniversary of Romance Philology : A homage volume dedicated to Jerry R. Craddock, containing a selection of his obra dispersa on Romance historical linguistics, pp. 1–42. page 5 http://www.jstor.org/stable/44741756
Further reading
“cancer”, in Charlton T. Lewis and Charles Short (1879) A Latin Dictionary, Oxford: Clarendon Press
“cancer”, in Charlton T. Lewis (1891) An Elementary Latin Dictionary, New York: Harper & Brothers
“cancer”, in The Perseus Project (1999) Perseus Encyclopedia