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1919, “Diseases of the Eye”, in Eye, Ear, Nose and Throat, volume 1919, page 103:
The "American ipecac" (E. ipecacuanha), sometimes used as a substitute for the true Brazilian article, is an eye irritant. The milk of the flowering spurge and the cypress spurge have caused some damage along this line ;
1930 April, W. C. Muenscher, “Leafy Spurge and Related Weeds”, in Cornell Extension Bulletin, volume 192, page 10:
Contact with the sap of leafy spurge and cypress spurge may result in skin blisters and inflamation, and with animals the hair may fall.
2002, “Cypress Spurge”, in Biological Control of Invasive Plants in the Eastern United States, page 205:
These growers had been harvesting cypress spurge infested hay and selling it for animal food or as construction hay, perhaps assisting the spread of cypress spurge to new areas.