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The origin of "guinea" in "guinea pig" is uncertain. One theory is that the animals, which are originally from South America, were brought to Europe by way of Guinea, leading people to think they had originated there.[1] "Guinea" was also frequently used in English to refer generally to any far-off, unknown country, and so the name may simply be a colorful reference to the animal's foreignness.[2] Others believe "guinea" may be an alteration of the word coney(“rabbit”); guinea pigs were referred to as "pig coneys" in Edward Topsell's 1607 treatise on quadrupeds.[1]
This etymology is missing or incomplete. Please add to it, or discuss it at the Etymology scriptorium. Particularly: “Where did the "experimental subject" sense come from? Guinea pigs are not commonly used for that these days.”
e spoke of the unwisdom of volunteering one's services as a guinea pig.
2008 October, Davy Rothbart, “How I caught up with dad”, in Men's Health, volume 23, number 8, →ISSN, page 112:
My dad told me about his days in the Navy: He'd agreed to be a guinea pig in exchange for a shorter enlistment. They kept him awake for a week straight.
(dated,slang) A professional company director, without time or real qualifications for the duties.
1779, Macintosh, Travels, quoted in Carey, Old Days, i. 73
I promise you, to me it was no slight penance to be exposed during the whole voyage to the half sneering, satirical looks of the mates and guinea-pigs.