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histotope. In DICTIOUS you will not only get to know all the dictionary meanings for the word
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English
Etymology
From histo- + -tope.
Noun
histotope (plural histotopes)
- The portion of an antigen that reacts with or binds to a T-cell.
1984, William E. Paul, Immunogenetics, page 156:Thus, a mutation affecting the structure of a class II molecule changes the co-recognition specificity of a histotope on the APC of the mutant.
2012, Benvenuto Pernis, Processing and Presentation of Antigens, page 117:However, this experiment by itself did not distinguish whether the change was in the desetope, which is the most straightforward interpretation, or in the histotope.
2012, Carl W. Pierce, Susan E. Cullen, Judith A. Kapp, Ir Genes: Past, Present, and Future, page 303:First, during ontogeny, T cells are positively selected by recognition of the histotope and then negatively selected by a tolerance mechanism or vice versa.