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From Old Latinstlocus, probably from Proto-Italic*stlokos, from Proto-Indo-European*stel-(“to put, place, locate”). However, De Vaan is skeptical of this derivation due to the suffix *-okos not being attested in any other word, and leaves the origin open.[1]
The inflection is irregular. For senses one and two, the declension follows the regular masculine pattern. For sense three, the plural forms become neuter in gender and form.
^ De Vaan, Michiel (2008) “locus”, in Etymological Dictionary of Latin and the other Italic Languages (Leiden Indo-European Etymological Dictionary Series; 7), Leiden, Boston: Brill, →ISBN, page 347
“locus”, in Charlton T. Lewis and Charles Short (1879) A Latin Dictionary, Oxford: Clarendon Press
“locus”, in Charlton T. Lewis (1891) An Elementary Latin Dictionary, New York: Harper & Brothers
locus in Charles du Fresne du Cange’s Glossarium Mediæ et Infimæ Latinitatis (augmented edition with additions by D. P. Carpenterius, Adelungius and others, edited by Léopold Favre, 1883–1887)
locus in Gaffiot, Félix (1934) Dictionnaire illustré latin-français, Hachette.
Carl Meißner, Henry William Auden (1894) Latin Phrase-Book, London: Macmillan and Co.
(ambiguous) pleasant districts; charming surroundings: loca amoena, amoenitas locorum
the fixed stars: sidera certis locis infixa
the situation of a place: situs loci
the natural position of a place: natura loci
the advantageous situation of a place: opportunitas loci (B. G. 3. 14)
to be separated by an immense interval of space and time: intervallo locorum et temporum disiunctum esse
in many respects; in many points: multis rebus or locis
on every occasion; at every opportunity: quotienscunque occasio oblata est; omnibus locis
the whole domain of philosophy: omnes philosophiae loci
the points on which proofs are based; the grounds of proof: loci (τόποι) argumentorum (De Or. 2. 162)
the lyric portions of a tragedy: loci melici
(ambiguous) to reconnoitre the ground: loca, regiones, loci naturam explorare
a town with a strong natural position: oppidum natura loci munitum (B. G. 1. 38)
this is not the place to..: non est huius loci c. Inf.
this is not the place to..: non est hic locus, ut...
this passage is obscure: hic (ille) locus obscurus est
(ambiguous) heights, high ground: loca edita, superiora
(ambiguous) rough and hilly ground: loca aspera et montuosa (Planc. 9. 22)
(ambiguous) level country; plains: loca plana or simply plana