methotrexate
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Chemical structure of methotrexate
See also: méthotrexate
English
Alternative forms
Etymology
Probably from metho- + tre- (“alteration of pteridine”) + (carbo)x(yl)ate.
Pronunciation
- (Received Pronunciation) IPA(key): /ˌmɛθ.əˈtɹɛk.seɪt/, /ˌmiː.θəˈtɹɛk.seɪt/
- (General American) IPA(key): /ˌmɛθ.əˈtɹɛkˌseɪt/
Noun
methotrexate (countable and uncountable, plural methotrexates) (abbreviated MTX)
- (pharmacology) An antimetabolite and antifolate drug used in treatment of cancer, autoimmune diseases, and ectopic pregnancies.
- 2010, Siddhartha Mukherjee, The Emperor of All Maladies, Fourth Estate (2011), page 133:
- One group would be treated with intensive methotrexate dosing, while the other group would be treated with milder and less intensive dosing.
Derived terms
- -trexate (“folic acid analog”)
Translations
antimetabolite and antifolate drug
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References
- “methotrexate”, in Lexico, Dictionary.com; Oxford University Press, 2019–2022.
- “methotrexate”, in Merriam-Webster Online Dictionary, Springfield, Mass.: Merriam-Webster, 1996–present.