misfold
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English
Etymology
Pronunciation
- (verb) IPA(key): /mɪsˈfoʊld/
Audio (Southern England): (file) - (noun) IPA(key): /ˈmɪsfoʊld/
Audio (Southern England): (file)
Verb
misfold (third-person singular simple present misfolds, present participle misfolding, simple past and past participle misfolded)
- (biochemistry, intransitive, of a protein or nucleic acid) To fold into an unusual or incorrect tertiary structure; misfolded proteins occur in various diseases, including amyloidoses and dementias, although the question of causation versus consequence is not yet definitively answered for dementias.
- 2021 March 1, Anderson, K.N., Overcast, W.B., Brosch, J.R., Graner, B.D., Veronesi, M.C., “Prionopathies and Prionlike Protein Aberrations in Neurodegenerative Diseases”, in American Society of Neuroradiology, volume 11, number 2, , pages 127-148:
- The prionopathies are best known among the neurodegenerative diseases for their ability to misfold, self-propagate, and infect other organisms.
Noun
misfold (plural misfolds)
- An incorrect or abnormal folding.