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English
Etymology
Blend of PAR + Thanatos (“Greek personification of death”)
Noun
parthanatos (uncountable)
- (physiology) A form of apoptosis associated with PARP.
2006, Seong-Woon Yu, “Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death”, in PNAS, volume 103, number 48:Our results suggest that excessive activation of PARP-1 leads to an intrinsic cell death program, which we designate as parthanatos to distinguish from necrosis and apoptosis.
2008, Gary E. Gibson, Mitochondria and Oxidative Stress in Neurodegenerative Disorders:Also, the lack of knowledge of mechanisms of calpain activation in parthanatos makes it difficult to identify calpain as PAR-dependent mediators of AIF release.
2010, Denson G. Fujikawa, Acute Neuronal Injury: The Role of Excitotoxic Programmed Cell Death Mechanisms:The biochemical features of parthanatos are distinct from classically defined pathways of cell death, and include rapid PARP-1 activation, early PAR accumulation, mitochondrial depolarization, early nuclear AIF translocation, loss of cellular NAD and ATP, and late caspase activation.