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From Middle English, borrowed from Middle French, from Medieval Latinquinta essentia(“fifth essence, aether”). "Essence" in this context is a synonym for "element". In pre-atomic/Aristotlean theory, there are four known elements or essences — Earth, Air, Fire and Water — and a putative fifth element (aether), which is considered to be of exceptional superior quality to the other four basic elements.
As families and kindreds sometimes do; producing, after long ages of unnoted notability, some living quintescence of all the qualities they had, to flame forth as a man world-noted […]
For vvhat is ſilke but eu'n a Quinteſſence, / Made vvithout hands beyond al humane ſenſe? / A quinteſſence? nay vvel it may be call'd, / A deathleſſe tincture, ſent vs from the skies, / VVhoſe colour ſtands, vvhose gloſſe is ne're appalld, […]
1667, John Milton, “Book VII”, in Paradise Lost., London: [Samuel Simmons], and are to be sold by Peter Parker; nd by Robert Boulter; nd Matthias Walker,, →OCLC; republished as Paradise Lost in Ten Books:, London: Basil Montagu Pickering, 1873, →OCLC, lines 243–245:
Let ther be Light, ſaid God, and forthwith Light, / Ethereal, firſt of things, quinteſſence pure, / Sprung from the Deep, […]