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2014 May 16, Katerina Spyridaki et al., “Structural-Functional Analysis of the Third Transmembrane Domain of the Corticotropin-releasing Factor Type 1 Receptor”, in The Journal of Biological Chemistry, volume 289, →DOI:
CRF and related peptides, such as sauvagine, bind to the extracellular regions of CRF 1 R and activate the receptor.