senolytic

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English

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Etymology

From seno- +‎ -lytic.

Noun

senolytic (plural senolytics)

  1. (medicine) Any drug that destroys senescent cells.
    • 2020, Anna Chang, Current Diagnosis and Treatment: Geriatrics, 3rd edition, McGraw Hill Professional, page 186:
      A number of senolytics have been identified by high-throughput screening or by targeting unique aspects of senescent cell biology.
    • 2022, Yuzhao Huang, Yuchen He, Meagan J. Makarcyzk, Hang Lin, Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes, Zhen Li, Laura Creemers, Xiaoling Zhang (editors), Regenerative Medicine for Cartilage and Joint Repair, Frontiers in Bioengineering and Biotechnology, page 14,
      Therefore, the treatment with senolytics may not be able to reverse the loss of chondrogenic potential in PDL9.
    • 2023, Arda Küçükgüven, Íbrahim Vargel, 16: Antiaging: Is it possible?, Ibrahim Vargel, Fatma Figen Özgür (editor), Beauty, Aging and AntiAging, Elsevier (Academic Press), page 157,
      It is important to reevaluate the efficacy of these senolytics for long-term use in antiaging, particularly if they were originally developed for short-term use.

Translations

Adjective

senolytic (not comparable)

  1. (medicine) That destroys senescent cells.
    • 2020, O. S. Barrera-Vázquez, Juan Carlos Gomez-Verjan, “12: Pharmacological Treatment for Aging: Are We There?”, in Juan Carlos Gomez-Verjan, Nadia Alejandra Rivero-Segura, editors, Clinical Genetics and Genomics of Aging, Springer, page 239:
      Senolytic compounds are agents that selectively induce death in senescent cells [69].
    • 2022, Naomasa Fukase et al., “Chapter 3: Interventional Strategies to Delay Aging-Related Dysfunctions of the Musculoskeletal System”, in Kunihiro Sakuma, Nobuo Morotomi, editors, Muscle Cell and Tissue, IntechOpen, page 34:
      The use of senolytic agents is a promising approach to delay aging and reduce the severity of chronic diseases through senescent cell depletion [58].
    • 2022, Jacques Ferreira, Alex Deamer, Chapter 13: Clearance of senescent cells: potent anti-aging approach, Sandeep Kumar Singh, Chih Li Lin, Shailendra Kumar Mishra (editors), Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging, Elsevier (Academic Press), page 299,
      However, fisetin, a quercetin derivative, is moderately senolytic to many cell types, including mesenchyme-derived cells (Sasaki, Sato, & Nakanuma, 2020; Yousefzadeh et al., 2018), despite only differing by a hydroxyl group.

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