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We have previously shown that the study of O-acetyl esters on the sialic acids is fraught with difficulties.
1987, American Journal of Medical Genetics, Volume 28, page 383:
Intralysosomal accumulation of free sialic acid both in vivo and in vitro in Salla disease is due to a defect of the transport mechanism of sialic acid in lysosomal membranes [Renlund et al, 1983b, 1986a, b; Mancini et al 1986].
1997, International Journal of Oncology, Volume 10, Issue 4, Lychnia, page 761,
Figure 3. Relationship between the disease-free survival rate and sialic acid expression in 100 breast cancer patients following curative surgery.