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Apparently from sweet + bread, though the reason is not immediately evident. Possibly connected with Dutch zwezerik, whose etymology is also unclear.[1]
SWEETBREAD SANDWICH: Cook sweetbreads until tender. When cold, remove skin, chop fine, season with salt and pepper, add one cup of finely chopped celery, and a dash of mayonnaise dressing; spread on thin slices of lightly buttered white bread. Cover with another slice and garnish with an olive.
2019, Bill Bryson, The Body: A Guide for Occupants, Black Swan (2020), page 177:
The pancreas of an animal when cooked for consumption is known as a sweetbread.
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