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2013 February, Bernard R. Lauwerys, Eric Hachulla, François Spertini et al., “Down-regulation of interferon signature in systemic lupus erythematosus patients by active immunization with interferon α–kinoid”, in Arthritis & Rheumatism, volume 65, number 2, →DOI, page 448:We are currently developing IFNα–kinoid (IFN-K) as an alternative treatment for SLE. Kinoids are composed of inactivated cytokines conjugated to a carrier protein, keyhole limpet hemocyanin (KLH), and are then injected as an emulsion with an adjuvant. In animal studies, immunization with kinoids induces high titers of polyclonal neutralizing antibodies against the targeted cytokine[.]