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From Middle Englishcros-, crosse-(“relating to a cross, forming a cross, in the shape of a cross or x”), from the noun (see cross) and also from across.
To crossfeed as to supply one fuel tank of an aircraft with fuel from another. To crossregulate is when one metabolic pathway is regulated by the enzymes in another pathway. These are one-way influences, whereas the previous sense of mutuality has symmetric two-way influences; e.g. crossrepression is mutual repression of interacting systems.