From hyper- + modified. <span class="searchmatch">hypermodified</span> (not comparable) highly modified (biochemistry, of bases or nucleosides) modified at multiple positions hypermodification...
has an article on: queuine Wikipedia queuine (uncountable) (biochemistry) A <span class="searchmatch">hypermodified</span> derivative of guanine present in the anticodon of some tRNAs...