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From Latinomicron, from Koine Greekὂ μῑκρόν(ò mīkrón, “littleo”), named in contrast with omega(“bigo”). The uncommon form omicra is similarly borrowed from Latin and Greek. The use for designating stars in a constellation—typically in order of apparent brightness—began with Johann Bayer's 1603 Uranometria.
1656 [1612], Henry, Earl of Monmouth, transl., I Raggvagli di Parnasso: or Advertisements from Parnassus, London: Humphrey Moseley, translation of De Ragguagli di Parnaso by Traiano Boccalini, page 180:
Your Majestie knows that unfortunate I [...] was the first who when I published my Poem of Italia Liberata endeavoured to bring the Omicron, Eupselon, Omega, and other Greek Letters, which I thought very requisite for that language, into my own Tongue;
1750 [1748 January 10], James Russel, “Letter LI”, in Letters from a Young Painter Abroad to his Friends in England, volume II, London: W. Russel, page 120:
The E serves both for the Epsilon and Eta; the O, both for the Omicron and Omega, and likewise for the dipthong OΥ.
1992 July, Astronomy Now, No. 36, p. 1:
... They include Mira itself (omicron Ceti) which can be seen shortly before dawn.
There are now seven “variants of interest” or “variants of concern” and they each have a Greek letter, according to a W.H.O. tracking page. Some other variants with Greek letters do not reach those classification levels, and the W.H.O. also skipped two letters just before Omicron — “Nu” and “Xi” — leading to speculation about whether “Xi” was avoided in deference to the Chinese president, Xi Jinping.