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The loose skin at the back of the neck of some animals.
(rare) The back of the neck, nape; also scruff of the neck.
He grabbed his unruly child by the scruff of the neck, and took him home.
Usage notes
Strictly refers to the loose skin at the back of the neck – found on many mammals, though not humans – rather than the back of the neck itself. While this distinction is not always observed, scruff is used almost exclusively in the phrase “to grab by the scruff ”.