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Popularized by the cartoon character Bugs Bunny as part of his catchphrase “Eh... What’s up, doc?”, as early as 1940. Originally a common greeting from Bugs Bunny creator Tex Avery's neighborhood in Taylor, Texas.
"What's up?" he asked, dropping back into a chair, and jingling the loose coins in his trouser pockets. / "I have had news of the Black Eagle," his father answered. "She is reported from Madeira."
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