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Made popular by the cartoon character Bugs Bunny as part of his catch phrase “What’s up Doc?”, as early as 1940. Originally a common greeting from Bugs Bunny creator Tex Avery's neighborhood in Taylor, Texas. [1]
Lady Frederick: Oh lord, I wish I were eighteen. [She sinks into a chair, and an expression of utter weariness comes over her face.] Gerald: I say, what's up? Lady Frederick:[Starting.] I thought you'd gone. Nothing.
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