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Alongside the root for "three" (*g-sum), this root for "two" is one of the most lexemically and phonologically stable numerals in Sino-Tibetan languages, and lexical replacement of this etymon is excessively rare: e.g. Jingpho /ləkhôŋ/ which has not been successfully connected to anything else. The Jingpho word for "one" has a similar shape, /ləŋâi/, and is also etymologically unclear.
This root appears unmistakably cognate with *s-ni-s(“seven”). See there for more.
The Burmese form seems to suggest a proto-language velar final variant: *-ik.