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From the Latin preposition cis(“on this side of”). The earliest known sexuality-related use of the prefix in any language was in a 1914 German-language book on sexology.[1] According to the Oxford English Dictionary, the earliest use of the prefix in the context of gender in English dates from 1994.[2]
In the first sense, “on this side of”, this prefix is usually attached directly to the word it modifies, or sometimes separated from it by a hyphen: cisrhenane, cis-Neptunian.
In the gender-related sense, this prefix is attached directly to certain words, most notably cisgender and cissexual (which are almost always spelled thus, not as e.g. *cis sexual). In other cases, the related standalone adjective cis is used: hence one speaks of a cis perspective (not *cisperspective), etc. Compare trans- and trans.
^ Ernst Burchard (1914) Lexikon des gesamten Sexuallebens (in German)
1914, Ernst Burchard, Lexikon Des Gesamten Sexuallebens, Berlin, BV047570799, page 32:
Cisvestitismus, die Neigung, die Kleidung einer anderen Altersstufe, Volks- oder Berufsklasse des gleichen Geschlechts zum Zwecke sexueller Entspannung anzulegen, dem Transvestitismus verwandt (s. Verkleidungstrieb).
Cisvestism, the tendency to don the clothes of a different age group, ethnic group, or profession of the same sex for the purpose of sexual relaxation, related to transvestism (see disguise instinct).
^ “New words notes December 2015 – Oxford English Dictionary”, in (Please provide the book title or journal name), 2017 November 7 (last accessed), archived from the original on 29 November 2017