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Borrowed from Frenchroulette(“roulette, little wheel”). The sense "situation with a random chance of incurring serious harm" may be abstracted from Russian roulette.
(uncountable,figuratively) An instance of risk-taking, especially when the downside exceeds the upside (contrary to the game of roulette where only the wager is lost).
Doctors and health officials said that the WRC-TV documentary, "DPT: Vaccine Roulette," emphasized the risks of the vaccine while ignoring the dangers of the disease, which has been almost wiped out in this country.