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1990 December 16, Phil Harper, “Affirmed”, in Gay Community News, volume 18, number 22, page 9:
In its synthesis of different art forms and various techniques, Tongues Untied actually represented a departure for Riggs, whose previous work […] had been in a relatively traditional documentary format.
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From Ancient Greekσύνθεσις(súnthesis, “a putting together; composition”), from συντίθημι(suntíthēmi, “put together, combine”), from σύν(sún, “together”) + τίθημι(títhēmi, “set, place”).
Being a word borrowed from English derived from Greek, the y in synthesis is pronounced /ɨ̞, ɪ/ rather than expected /ə/. To preserve consistency between pronunciation and spelling, some prefer to spell this word sunthesis. Nevertheless, synthesis is the more common spelling of the two. See pyramid/puramid, symbol/sumbol, system/sustem for similar examples.
R. J. Thomas, G. A. Bevan, P. J. Donovan, A. Hawke et al., editors (1950–present), “synthesis”, in Geiriadur Prifysgol Cymru Online (in Welsh), University of Wales Centre for Advanced Welsh & Celtic Studies